Childhood cancers in families with and without Lynch syndrome
نویسندگان
چکیده
منابع مشابه
Genetic anticipation in Swedish Lynch syndrome families
Among hereditary colorectal cancer predisposing syndromes, Lynch syndrome (LS) caused by mutations in DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2 is the most common. Patients with LS have an increased risk of early onset colon and endometrial cancer, but also other tumors that generally have an earlier onset compared to the general population. However, age at first primary cancer varies ...
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1 Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway, 2 Unit of Muscle Biology, Lund Transgenic Core Facility/Reproductive Immunology, Department of Experimental Medical Science, Lund University, Lund, Sweden, 3 Institute of Basic Sciences and Experimental Medicine (ICBME), Instituto Universitario Hospital Italiano, Buenos Aires, Argentina, 4 Prog...
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Lynch syndrome (LS) is characterized by an autosomal dominant inheritance of the early onset of colorectal cancer (CRC) and endometrial cancer, as well as increased risk for several other cancers including gastric, urinary tract, ovarian, small bowel, biliary tract, and brain tumors. The syndrome is due to a mutation in one of the four DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, or PMS2. ...
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We are delighted to have the opportunity to respond to the letter by Gilks et al. (Gilks et al., 2017). They argue first that historical pathological entities do not map seamlessly to modern day diagnostic categories, which are not only based on expert review by specialist gynecological pathologists but are also increasingly supported by immunohistochemistry (IHC). Second, that the misclassific...
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Chicago, said her center has been doing Iort with an Intrabeam for nearly a year and has treated about 50 patients so far. “We don’t have a strict protocol,” she said, “but we tend to use it on women in their 60s who have relatively small, invasive [ductal] cancers.” “Patients love it,” said hansen. But it’s frustrating for those who find out later, from the final pathology report, that they ha...
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ژورنال
عنوان ژورنال: Familial Cancer
سال: 2015
ISSN: 1389-9600,1573-7292
DOI: 10.1007/s10689-015-9810-3